Handbook of Pre-clinical Continuous Intravenous Infusion

Edited by Guy Healing & David Smith, 330 pages, Taylor & Francis, 2000. ISBN 978-0748408672.

Instech review: the first of its kind in infusion research, this book provides a good overview of surgical procedures, equipment and practical tips for a wide range of laboratory animal species. It is focused on toxicity testing during pre-clinical pharmaceutical development, though many aspects, such as the surgical techniques, have broader application. Each chapter has been written by an expert in the field. Written in 1998-1999 and published in 2000, it is generally up-to-date, though some advances in equipment, such as our mouse infusion harness, are not reflected in the contents.

Table of Contents

Part 1: Continuous Intravenous Infusion in the Rat

1. Femoral cannulation using the jacket/harness model in the rat (O. P. Green and D. Patten)
2. Femoral cannulation using the tail cuff exteriorisation model in the rat (A. M. McCarthy)
3. Tethering and the implanted button model in the rat (E. S. Miedel)
4. Multidose infusion toxicity studies in the rat (G. Healing)
5. Reproductive toxicology studies by infusion in the rat (P. C. Barrow)

Part 2: Continuous Intravenous Infusion in the Mouse

6. Femoral cannulation using the tail cuff model in the mouse (H. Van Wijk and D. Robb)
7. Multidose infusion toxicity studies in the mouse (H. Van Wijk and D. Robb)
8. Jugular cannulation and efficacy studies in the mouse (I. Horh)

Part 3: Continuous Intravenous Infusion in the Rabbit

9. Femoral cannulation of the rabbit for reproductive toxicity studies (C. Copeman and K. Robinson)
10. Jugular catheterisation of the rabbit for reproductive toxicity studies (E. Gordon and S. Lynch)

Part 4: Continuous Intravenous Infusion in the Dog

11. Jugular cannulation in the dog (N. Pickersgill)
12. The non-ambulatory model in dog multidose infusion toxicity studies (N. Pickersgill and R. Burnett)
13. The ambulatory model in dog multidose infusion toxicity studies (T. R. Gleason and C. P. Chengelis)

Part 5: Continuous Intravenous Infusion in the Primate

14. Surgical preparation and infusion of the large primate (V. Mendenhall, S. Cornell and M. A. Scalaro)
15. Multidose infusion toxicity studies in the large primate (M. D. Walker)
16. Surgical preparation and multidose infusion toxicity studies in the marmoset (C. R. Schnell)

Part 6: Continuous Intravenous Infusion in the Minipig

17. Surgical preparation of the minipig (P. Brinck)
18. Multidose infusion toxicity studies in the minipig (P. Brinck)
19. Reproductive infusion toxicity studies in the minipig (P. A. McAnulty)

Part 7: Continuous Intravenous Infusion - General

20. Common pathological findings in continuous infusion studies (J. G. Evans and P. J. Kerry)
21. The use of mini-osmotic pumps in continuous infusion studies (L. Perkins, C. Peer and P. Murphy-Hackley)
22. The contribution of vehicles, rates of administration and volumes to infusion studies (K. Hickling and D. Smith)
23. Equipment for continuous intravenous infusion (A. Jacobson)